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| • | 86: COMBO PACK TELESCOPE + MICROSCOPE - DELUXE SET + | ||
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| • | Ocean Acidification From Carbon Dioxide Emissions Will Cause Physiological Impairment To Jumbo Squid | ||
| The elevated carbon dioxide levels expected to be found in the world's oceans by 2100 will likely lead to physiological impairments of jumbo squid. | |||
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| • | 3-D Cell Growth: Engineers' New Microfluidic Device Could Help With Drug Development | ||
| Engineers have built a device that gives them an unprecedented view of three-dimensional cell growth and migration, including the formation of blood vessels and the spread of tumor cells. | |||
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| • | Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor | ||
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In assisted reproductive technology, human chorionic gonadotrophin (hCG) is administered subcutaneously for the induction of oocyte maturation and ovulation. Our efforts to develop orally bioavailable luteinizing hormone (LH) receptor agonists have led to the discovery of Org 43553, a low molecular weight (LMW) LH receptor (LH-R) agonist. Org 43553 was tested in vitro and in vivo in pre-clinical pharmacological models to demonstrate efficacy and oral availability. Org 43553 is a potent stimulator of the human LH-R in vitro (EC50 3.7 nM). In primary mouse Leydig cells, Org 43553 stimulated testosterone production. Pharmacokinetic analyses showed high oral bioavailability in rats (79%) and dogs (44%) with a shorter half-life compared with hCG (3.4 versus 5.6 h in the rat). Ovulation induction by Org 43553 was demonstrated in immature mice as well as in cyclic rats after single-dose oral administration (50 mg/kg). The ovulated oocytes were of good quality as demonstrated by successful fertilization and implantation of normal embryos. In male rats, testosterone production was substantially induced after oral administration. Org 43553 is the first LMW LH-R mimetic with demonstrated in vivo efficacy upon oral administration and could therefore replace subcutaneously administered hCG. The elimination half-life of Org 43553 is substantially shorter than hCG, which could potentially represent a clinical benefit in reducing the risk of ovarian hyperstimulation syndrome (OHSS). |
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| • | RPI Mourns the Passing of Ned Harkness | ||
| September 19, 2008: Rensselaer lost a legend when Ned Harkness passed away at the age of 89 on Friday morning. Harkness, who coached RPI men's hockey and men's lacrosse teams to National Championships, died at his home in Rochester, N.Y. A memorial service is being planned for 11 a.m. on Oct. 11 at the First Presbyterian Church in Glens Falls, N.Y. | |||
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| • | Naked Scientists 08.06.08 - The Secrets of Odysseus | ||
| Ancient Greece is on the naked scientists' menu this week as we travel back in time to 1200 BC to discover how modern science and a 3000 year old poem have solved an ancient riddle. A team of classicists, geologists and archaeologists claim to have found the island of Ithaca, home of the legendary Greek hero Odysseus. Digging further into the past we also hear how geophysics can help archaeologists to see what lies buried underground but without having to lift a trowel. We also learn how dormant brain stem cells can be brought back to life, why it's not just size that is important when it comes to brains, and the mind-controlling parasite that turns its host first into an egg-incubator and then into a bodyguard. Plus, in Kitchen Science, savouring the Greek flavour, Ben and Dave recreate the science of the original Naked Scientist, Archimedes, and find out whether a heap of gold coins are the real thing... | |||
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| • | SARS Virus Recreated: Opens Door For Potential Defenses Against Future Strains | ||
| Researchers have synthetically reconstructed the bat variant of the SARS coronavirus that caused the SARS epidemic of 2003. | |||
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| • | Alan Rose at Helen Newman Hall. | ||
| Alan Rose changed his sedentary lifestyle with the help of the Cornell Program for Healthy Living. He now works out three times a week at Helen Newman Hall. | |||
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| • | UD's Buchanan earns professional recognition | ||
| Thomas S. Buchanan, professor of mechanical engineering and deputy dean in the College of Engineering at the University of Delaware, has been elected a fellow of two professional societies -- the American Institute for Medical and Biological Engineering (AIMBE) and the American Congress of Sports Medicine (ACSM). | |||
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| • | Endoscope Instruments | ||
| High quality Endoscope Instruments at the most Affordable Prices. | |||
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| • | MicroSCoPE: November, 2005 Issue | ||
| by Sylvia Currie. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ |
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| • | 7.547J Principles and Practice of Drug Development, Fall 2005 (MIT) | ||
| See description under subject 15.136J. Description from the course home page: This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate. | |||
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| • | Metabolic Reactions: Less Is More In Single-celled Organisms | ||
| A new study of four single-celled organisms had some surprising results. The organisms, which differed in size and complexity of each organism's genome, used the same number of biochemical reactions when optimizing growth. And, contrary to what you might expect, each, to efficiently perform metabolic tasks such as growing fast or converting sugars to ethanol, tended to use only a small fraction of the biochemical reactions available to them in the metabolic network. | |||
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| • | How Plants Fine Tune Their Natural Chemical Defenses | ||
| Even closely related plants produce their own natural chemical cocktails, each set uniquely adapted to the individual plant's specific habitat. Comparing antifungals produced by tobacco and henbane, researchers have discovered that only a few mutations in a key enzyme are enough to shift the whole output to an entirely new product mixture. | |||
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| • | Statistical optimization of medium composition for aspergiolide a production by marine-derived fungus aspergillus glaucus. | ||
| Statistical optimization of medium composition for aspergiolide A production by marine-derived fungus Aspergillus glaucus. J Ind Microbiol Biotechnol. 2008 Dec 23; Authors: Cai MH, Zhou XS, Sun XQ, Tao KJ, Zhang YX Statistical methodologies were employed to optimize submerged culture medium for the production of a novel antineoplastic compound aspergiolide A by a marine-derived fungus Aspergillus glaucus HB1-19 for the first time. Orthogonal design was preformed to determine the initial composition. Then Plackett-Burman design was applied to evaluate the influence of related nutrients, and yeast extract paste, soybean powder and sodium glutamate were confirmed as critical factors in the medium. Response surface methodology (RSM) was finally taken as an effective approach to opt... | |||
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| • | Exercise affects platelet-impeded antitumor cytotoxicity of natural killer cell. | ||
| Page: 115DOI: 10.1249/MSS.0b013e3181831f27Authors: WANG, JONG-SHYAN 1,2; CHUNG, YEE 1; CHOW, SHU-ER 3 (Source: Medicine & Science in Sports & Exercise) | |||
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| • | NEW Trinocular Polarizing Microscope w compensators | ||
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| • | Young age may offer survival advantage to children with DPG | ||
| St. Jude investigators have shown that children under 3 years old who have a brain tumor called diffuse pontine glioma (DPG) appear to have a better outcome than older children with the same cancer. | |||
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| • | ScienceOnline'09 - introducing the participants [A Blog Around The Clock] | ||
So, let's highlight some of the participants of this year's ScienceOnline09 conference: Eva Amsen is a newly-minted PhD in Biochemistry at the University of Toronto, and she blogs on Easternblot, Expression Patterns and Musicians and Scientists. Melissa Anley-Mills is the News Director in the Office of Research and Development at the U.S. Environmental Protection Agency. Samia Ansari is a Biochemistry Undergraduate student at the University of Georgia, and she blogs on 49 percent. She will co-moderate the session on Race in science - online and offline. Apryl Bailey is the Creative Director and Production Manager at SciVee.tv. She will co-moderate the session Not just text - image, sound and video in peer-reviewed literature and will also do a demo of SciVee.tv. Stacy Baker teaches high-school biology. She also writes a blog about the use of technology in teaching - Using Blogs in Science Education - and runs, together with her students, a classroom blog Extreme Biology (which just received the EduBlog2008 Award). Miss Baker and eight of her students will lead the session Science online - middle/high school perspective (or: 'how the Facebook generation does it'?). Enrico Maria Balli is one of the founders and the CEO of Sissa Medialab in Trieste, Italy. Meredith Barrett is a Ph.D Student in the Duke University Program in Ecology at the Nicholas School of the Environment and writes (from the field, in Madagascar) her blog Lemur health & conservation. Karl Leif Bates is the Editor of Duke Research which is published by the Duke University Office of News & Communications and is a SCONC board member. Arati Bechtel writes the JMP Blog. JMP is Statistical Discovery Software from SAS. Callan Bentley is a geology professor at Northern Virginia Community College, writing NOVA Geoblog. Mike Bergin is well known to the readers of my blog, as the blogger at 10000birds and the manager of I and the Bird blog carnival. He will moderate the session Blog carnivals: why you should participate. Peter Binfield is a physicist and the Managing Editor of PLoS ONE. Larry Boles works at the Museum of Life + Science in Durham and blogs on their MLS Animal Department blog. Mauricio Borgen is the IT Administrator at Athenix Corp. Jean-Claude Bradley is a professor of chemistry at Drexel University. He is the pioneer of the Open Notebook Science movement, which you can see in action on his blog Useful Chemistry and the lab wiki UsefulChem Project. He will co-moderate the session Open Notebook Science - how to do it right (if you should do it at all) Bjorn Brembs is a neuroscientist at Freie Universitat Berlin and a science blogger. Chris Brodie is the vice president of corporate communications at the North Carolina Biotechnology Center and one of the founders and board members of SCONC. Daniel Brown is an IRTA Fellow in the Polypeptide Hormone Action Group at the National Institute of Environmental Health Science and blogs on Biochemicalsoul. Christine Bruske-Flowers works in the Office of Communications for the National Institute of Environmental Health Science. Steve Burnett is a musician, an acoustic ecologist and a blogger here in the Triangle. Read the comments on this post... |
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| • | The effect of delivery via narrow-bore needles on mesenchymal cells. | ||
| Conclusions: This study highlights potential parameters, such as minimizing the time period the cells are within the syringe and the use of wider-bore needles, involved in maintaining the high viable cell density required for the delivery of cell suspensions for cell therapy applications. PMID: 19105616 [PubMed - in process] (Source: Regenerative Medicine) | |||
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By editors@medicalnewstoday.com (MNT Editors) - Copyright 2008, Brightsurf.com - version: v1.5 build A
