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| • | Combo 60-100X& 30X Illuminated LED Microscope Magnifier | ||
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| • | Biological alternatives to chemical pesticides | ||
| With increasing consumer pressure on both farmers and supermarkets to minimise the use of chemical pesticides in fruit and vegetables, a new study, funded by the Economic and Social Research Council (ESRC), looks at why there is currently little use of biological alternatives in the UK. (2008-10-08) | |||
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| • | Just A Little Squeeze Lets Proteins Assess DNA | ||
| To find its target, all a protein needs to do is give quick squeezes as it moves along the DNA strand, suggests new research. Scientists had thought DNA-binding proteins primarily used full-body hugs for accurate readings of the information coded in the DNA's sequence. Doing the quick squeezes that scientists call indirect readout probably works faster, the researchers said. The finding has implications for the development of designer drugs. | |||
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| • | Genetic Diseases More Complicated: Mechanism Underlying Alternative Splicing Of Premessenger RNA Into Messenger RNA Discovered | ||
| A professor of medicine and biochemistry has discovered an unexpected mechanism governing alternative splicing. The new mechanism suggests that curing the more than half of genetic diseases that are caused by mutations in the genetic code that in turn create mistakes in alternative splicing may be considerably more complicated than researchers have previously assumed. | |||
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| • | An RCT of metformin versus orlistat for the management of obese anovulatory women | ||
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Treatment of obesity-related anovulation poses a significant clinical challenge. Occasionally, the use of antiobesity medications such as orlistat or insulin sensitizing agents such as metformin is sometimes indicated in these patients. This study aimed to compare the effects of metformin and orlistat for improving ovulation in obese anovulatory women. This was an open-label RCT. A total of 40 women were randomized to receive either metformin (n = 20) or orlistat (n = 20). BMI as well as the androgen profile and the ovulatory status were assessed at baseline and at four weekly intervals for 3 months. Different anthropometric and endocrine parameters were also assessed as possible predictors of ovulation. There was no significant difference between the two study arms regarding the ovulation rate for metformin and orlistat [40% (n = 8/20) and 25% (n = 5/20), respectively, P = 0.31]. Both arms showed a significant drop in the BMI, testosterone and androstendione concentrations (P < 0.05), but there was no difference between the two arms. Patients who ovulated had significantly lower concentrations of baseline LH, androstendione, dehydroepiandrosterone and free androgen index (P < 0.05). Among these factors, a low baseline LH was found to be the only independent predictor of ovulation (area under curve, 0.85). Both metformin and orlistat show a similar effect on weight loss, ovulation rates and androgen concentrations. However, the effects on ovulation rates need to be confirmed in larger studies. The presence of a low baseline serum LH was found to be the most important predictor of ovulation. |
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| • | Intel To Sponsor Rensselaer Robotics Tournament for Local Middle Schools | ||
| November 11, 2008: Intel Corporation announced plans to sponsor the 2008 FIRST LEGO® League (FLL) Climate Connections Challenge taking place at Rensselaer. | |||
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| • | Naked Scientists 08.10.05 - Catching Up with Cancer | ||
| We catch up with the latest on cancer this week including an update from the National Cancer Research Institute conference in Birmingham. We hear how computers are helping doctors to read mammograms, how researchers are re-programming the immune system to attack tumours, and we get the low down on the new vaccine against cervical cancer. We also discover how blood cells can be used as a Trojan horse to sneak-in chemicals to boost the power of body scans, what a fossil form of HIV can tell us about the origin of AIDS, and how beetles create their own antibiotics. Plus, in kitchen science, Ben and Dave use the power of steam to crush cans! | |||
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| • | Charting HIV's Rapidly Changing Journey In The Body | ||
| HIV is so deadly largely because it evolves so rapidly. With a single virus as the origin of an infection, most patients will quickly come to harbor thousands of different versions of HIV, all a little bit different and all competing with one another to most efficiently infect that person's cells. Now scientists have settled a longstanding question about just how HIV morphs in the body. | |||
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| • | 2008 Pic of the Day Slideshow | ||
| University Photography pic of the day gallery and slideshow for 2008. | |||
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| • | UD Energy Institute hosts symposium to form campus partnerships | ||
| A half-day symposium held Friday at Clayton Hall brought together more than 30 University of Delaware researchers with interests in the field of energy to share highlights of their work and stimulate collaboration. | |||
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| • | Pyruvate Kinase and Phosphoenolpyruvate Carboxykinase Activity in Adult Isoparorchis hypselobagri (Digenea:Trematoda) | ||
| The specific activity of pyruvate kinase (PK) and phosphoenolpyruvate carboxykinase (PEPCK) of adult I. hypselobagri regulates the glycolysis and CO2 fixation pathway. The PK activity is extremely low, 18.96°0.54 nmol/min/mg proteins, in I. hypselobagri, which is further depleted in in vitro starvation. The PEPCK activity in I. hypselobagri is more or less ten times higher than PK activity, 182°0.1 nmol/min/mg protein, which is further increased in in vitro starvation. The phosphoenolpyruvate (PEP) content of the fresh control fluke varies between 0.532 to 0.608 μmol/mg protein with an average value of 0.556°0.024 μmol/mg protein which is utilized during in vitro starvation. The ratio of PK/PEPCK in fresh fluke is 0.104, which gradually decreases during in vitro starvation period. The PK/PEPCK ratio indicates the CO2 fixation pathway and reverse TCA cycle of energy metabolism is operative in this parasite of swim bladder of Wallago attu. | |||
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| • | Vampire Bats | ||
| Vampire Bats Information, facts, behavior, diet, food, pictures, habitat and everything about Bats. | |||
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| • | SCoPE site back up | ||
| by Sylvia Currie. Hello everyone,
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| • | Validating census methods to measure changes in house mouse populations | ||
| BACKGROUND: Tracking and census baiting are two techniques that are commonly advocated for monitoring the size of mouse populations. However, currently these techniques are only able to provide an index of population size, rather than an assessment of absolute numbers. In this study the authors tested the reliability of both tracking (footprints left on tiles of fixed size) and census baiting as indices of population size, and sought to calibrate levels of activity and bait consumption under both semi-natural and field conditions (inside farm buildings).RESULTS: Under semi-natural conditions, census baiting produced more satisfactory population estimates than those derived from tracking activity. An initial field trial established that the optimum bait point density for this technique was 1 point per 2 m. Subsequent field trials demonstrated that the bait census technique offers a way to estimate the approximate size of stable populations of mice (population size = (mean daily bait consumption - 36.3)/2.46).CONCLUSION: The results to date are sufficiently encouraging to support the use of this cost-effective approach to monitoring mouse numbers in the type of habitats investigated in this study. © Crown copyright 2008. Reproduced with the permission of Her Majesty's Stationery Office. Published by John Wiley & Sons, Ltd. | |||
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| • | 7.340 Immune Evasion: How Sneaky Pathogens Avoid Host Surveillance, Spring 2004 (MIT) | ||
| This course is an advanced undergraduate seminar based upon discussions and critical analysis of primary literature in the field of immunology. Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease specific immune evasion and the mechanisms used by pathogens to prevail over their host's immune systems are discussed. What these host-pathogen interactions reveal about the normal function of the immune system and about basic cell biological processes, such as protein maturation and degradation, are also considered. | |||
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| • | MRSA Infections Continue To Fall, UK | ||
| MRSA bloodstream infections in England are continuing to fall, the latest quarterly statistics from the Health Protection Agency (HPA) showed today. There were 725 MRSA bloodstream infections in England between July and September. This represents a 13% decrease on the previous quarter (April to June) when there were 837 cases and a 33% reduction in the corresponding quarter of 2007. | |||
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| • | Examination Of Widely Used Antimicrobial Compound Reveals New Strategies To Fight Malaria | ||
| Scientists working on a common antimicrobial compound with antimalarial activity have discovered a range of new therapeutic strategies to combat malaria. The research, published in the journal Cell Host and Microbe, provides valuable insight into how the human malaria parasite's requirement for fatty acids can be exploited as it progresses through the distinct stages of its complex life cycle. | |||
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| • | New Type Of Diesel Fuel Found In Patagonia Fungus | ||
| Scientists have found a fungus that produces a new type of diesel fuel. One of the researchers calls it "myco-diesel." The discovery may offer an alternative to fossil fuels, according to a professor of plant sciences and plant pathology involved in the research. The find is even bigger, he said, than his 1993 discovery of fungus that contained the anticancer drug taxol. | |||
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| • | Method For Generating Novel Types Of Stem Cells | ||
| Breakthrough may offer opportunity for expanding research, drug discovery The study, which appears in the online version of Cell Stem Cell and the January 2009 print edition of the journal, provides proof of principle that alternative sources of stem cells can be created. | |||
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| • | Induction of iodide uptake in transformed thyrocytes: a compound screening in cell lines | ||
| Conclusion We hypothesize that testing of cells from primary tumours or metastases in patients may be a way to identify compounds with optimum therapeutic efficacy for individualized treatment. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-008-1024-6Authors Eleonore Fröhlich, University of Tuebingen Department of Endocrinology, Metabolism, Nephrology and Clinical Chemistry, Internal Medicine Otfried-Muellerstrasse 10 72076 Tuebingen GermanyPeter Brossart, University of Tuebingen Department of Haematology, Oncology, Immunology and Rheumatology, Internal Medicine Otfried-Muellerstrasse 10 72076 Tuebingen GermanyRichard Wahl, University of Tuebingen Department of Endocrinology, Metabolism, Nephrology and Clinical Chemistry, Internal Medicine Otf... | |||
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| • | Junior doctors 'don't understand lab tests' | ||
| The elimination of pathology and laboratory medicine from the curriculum in many medical schools and consequent lack of knowledge of basic science among junior doctors is jeopardising patient safety, says a report in the Annals of Clinical Biochemistry. (Source: The Royal Society of Medicine) | |||
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| • | 40x-400X ORE ROCK POLARIZING PETROGRAPHIC MICROSCOPE | ||
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| • | Bioinformatics in tropical disease research : a practical and case-study approach | ||
| This book serves as a textbook for short bioinformatics courses. Part A deals with bioinformatics techniques and part B deals with case studies. Each chapter in part A covers a specific problem in bioinformatics and consists of theory and tutorials with practical applications of that theory, using freely available software. Part B chapters covers reviews of human diseases, including bioinformatics approaches which have helped to solve particular problems. The book covers Linux, database design, similarity searches, protein structure, control of gene expression, proteomics, ESTs, alternative splicing and transgenic vectors. The book was edited by Gruber, Arthur; Durham, Alan M.; Huynh, Chuong; del Portillo, Hernando A. It was made available on the Web by the National Center for Biotechnology Information (NCBI) from their ‘Bookshelf’ where a collection of biomedical books have been adapted for the Web. | |||
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| • | Drug combination for non-Hodgkin lymphoma produces fewer side effects | ||
| A new combination of anti-cancer drugs, when integrated into an existing treatment for non-Hodgkin lymphoma, causes reduced risk for side effects in children than the conventional regimen. | |||
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| • | By: unrepentanthippie | ||
| "Went over" in this context means to their website, as I couldn't find it on any of the big box websites they claimed carried it, but I will post an update when they get here, I promise. | |||
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| • | Science Update Podcast for 12 September 2008 | ||
| THINGS THAT FLY: How bats can hear themselves, Bats and windmills don't mix, Big bird brains evolved faster, and how DEET really works. |
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| • | Are the male editors of Men's Health all virgins? [Dr. Joan Bushwell's Chimpanzee Refuge] | ||
Or are they channeling characters from 80's flicks like Weird Science and Revenge of the Nerds? Read the comments on this post... |
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| • | Mind and Body Cast - Episode 9 - Tea | ||
| Welcome to Mind and Body Cast, Episode #9, for January, 2007 Tea Visit our website at: http://www.MindandBodyCast.com Email us at: MindandBodyCast@gmail.com
Show Segments: v Intro Ø how to contact us – check out our website at http://www.MindandBodyCast.com Ø email us at MindandBodyCast@gmail.com Ø today’s topic and upcoming segments A. “In the Reader” weekly news |
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| • | Contract To Boost Health Research Capacity In Malawi Won By LATH | ||
| Liverpool Associates in Tropical Health (LATH), a consulting arm of Liverpool School of Tropical Medicine, has been awarded a £10 million contract to manage a programme of work supporting a new Health Research Capacity Strengthening (HCRS) initiative in Malawi. | |||
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| • | New CU-Boulder study shows diversity decreases chances of parasitic disease | ||
| A new University of Colorado at Boulder study showing that American toads who pal around with gray tree frogs reduce their chances of parasitic infections known to cause limb malformations has strong implications for the benefits of biodiversity on emerging wildlife diseases. (2008-10-22) | |||
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| • | Nurse practitioner management of acute in-hours home visit or assessment requests: a pilot study. | ||
| CONCLUSION: Nurse practitioner management of acute in-hours care requests, including home visits, appears feasible in practice and merits further assessment. PMID: 19105910 [PubMed - in process] (Source: The British Journal of General Practice) | |||
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By editors@medicalnewstoday.com (MNT Editors) - Copyright 2008, Brightsurf.com - version: v1.5 build A